Study finds, Perinatal blood biomarkers for the identificati
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A Study was conducted to determine if blood biomarkers measured at delivery and shortly after birth can identify growth-restricted infants at risk for developing severe brain injury.

In a cohort of very low birth weight neonates, fetal growth restricted (FGR) (birth weight less than 10%) were compared to non-FGR neonates, and within the FGR group those with brain injury were compared to those without. Biomarkers were measured in cord blood at delivery, and daily for the 1st 5 days of life.

Results:
--FGR was associated with significantly higher levels of interleukin (IL)-6, IL-8, IL-10, and lower levels of vascular endothelial growth factor (VEGF).

--FGR and brain injury were associated with significantly higher levels of IL-6, IL-8, IL-10, and glial fibrillary acidic protein (GFAP).

In conclusion, Interleukins can be engaged through both growth restriction as well as brain injury in a similar route, and within this growth-restricted group, GFAP may contribute in identifying brain lesions.

Source: https://www.nature.com/articles/s41372-021-01112-8
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