Study finds, Pretarsal Botulinum Toxin Injection in Benign E
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A Study was conducted to compare the ocular complications and efficacy of preseptal (PST) versus pretarsal (PTS) botulinum toxin type A (BoNT-A) injection in benign essential blepharospasm (BEB).

A total of 24 people with BEB were enrolled in the study. One eye was randomized to receive PST BoNT-A injection and the other eye was randomized to receive PTS BoNT-A injection of the same amount from a single investigator.

The symptoms of tearing, lagophthalmos, ptosis, and diplopia were collected at baseline, 1 and 3 months after the injection, and the marginal reflex distance (MRD) 1 (mm), MRD 2 (mm), degree of lagophthalmos (mm), presence of ectropion, entropion, ocular motility limitation, tear film breakup time (second), Schirmer's test (mm), ocular surface staining score (Oxford scheme), and Jankovic rating scale of both eyes separately were measured.

Results:
--There were statistically significant higher rate of self-reported lagophthalmos in PTS (n=12) than PST (n=7) BoNT-A injection, and significant higher estimated measured lagophthalmos in PTS (0.59 mm) than in PST (0.26 mm) injection at 1 month using interaction model.

--No significant difference in the efficacy and other complication outcomes between the injection locations was observed.

Finally, for blepharospasm, pretarsal BoNT-A injection resulted in a higher incidence of lagophthalmos than preseptal BoNT-A injection.

Source: https://www.ajo.com/article/S0002-9394(21)00228-2/fulltext?rss=yes
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