Study finds, Progressive retinal nerve fibre layer thinning
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A Study was conducted to investigate whether parapapillary choroidal microvasculature dropout (MvD) is associated with progressive retinal nerve fibre layer (RNFL) thinning in eyes with primary open-angle glaucoma (POAG) and disc haemorrhage (DH).

In 50 eyes with POAG and DH, swept-source optical coherence tomography (OCTA) angiography (OCTA) was used to assess parapapillary microvasculature 1 year before, at the time of, and 1 year after the detection of DH. MvD was identified as an area of focal sectoral dropout in the parapapillary deep layer with no visible microvascular network. The thickness of the RNFL on OCT was compared in groups of eyes with and without MvD.

Results:
--Cumulative prevalence of MvD was 76.0% at 1 year after detection of DH.

--All MvDs were detected in the same sectoral locations as DH. In eyes with MvD, global RNFL thickness and sectoral RNFL thickness at the location of DH were significantly reduced, both from 1 year before to the time of DH detection and from DH detection to 1 year later.

--In eyes without MvD, however, the reductions in global and sectoral RNFL thickness were significant only from DH detection to 1 year later.

Finally, in eyes with POAG, RNFL thinning was spatially consistent and progressive at the site of MvD, which was followed by DH, and it continued to improve after DH. Progressive RNFL thinning was more likely to occur after the detection of DH when DH was not accompanied by MvD.

Source: https://bjo.bmj.com/content/105/5/674?rss=1
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