Study finds, Recipient Factors Associated With Graft Detachm
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A Study was conducted to evaluate the recipient factors associated with graft detachment in the subsequent eye of patients who underwent sequential Descemet membrane endothelial keratoplasty (DMEK).

A case series of 158 eyes from 79 patients who had DMEK operations in both eyes for Fuchs endothelial dystrophy therapy were included. The primary outcome measure was the occurrence of graft detachment (any amount of detachment) in the subsequent eye at 1 week postoperatively. On graft detachment, the effects of preoperative, intraoperative, and postoperative factors were examined.

Results:
--Of 79 patients (158 eyes) with a mean follow-up of 11.7 ± 8.4 months, 18 patients (36 eyes) developed graft detachment in both eyes 1 week postoperatively.

--The risk of detachment in the subsequent eye was increased when the first eye had any amount of detachment [odds ratio = 2.8].

--When the first eye had a clinically significant detachment (more than 30% detached), the risk of detachment occurring in the subsequent eye was greater (odds ratio = 15.7).

--This risk of graft detachment in the subsequent eye increased 33% for every 5% increase in the detachment percentage in the first eye (odds ratio = 1.3).

Finally, graft detachment following DMEK raises the risk of graft detachment during subsequent DMEK in the contralateral eye. When graft detachment occurs after DMEK in the first eye, changes in perioperative treatment and surgical procedure in the contralateral eye, such as a larger gas bubble, use of SF6 20%, and combining cataract surgery, may be required.

Source: https://journals.lww.com/corneajrnl/Abstract/2020/10000/Recipient_Factors_Associated_With_Graft_Detachment.6.aspx
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