Study finds, Respiratory Function in Children with Nephrotic
A Study was conducted to evaluate the respiratory functions of children with nephrotic syndrome (NS) by impulse oscillometry (IOS) and its correlation with spirometry.

55 NS patients aged 3–18 years were included as the study group and 40 healthy children of the same age formed the control group. Patients were divided into nephrotic phase (first attack and relapse) and remission. Demographic, anthropometric and laboratory data of the children were recorded. Respiratory functions were evaluated by IOS and spirometry. Children over 6 years old performed both IOS and spirometry while children under 6 years performed only IOS.

Results:
--The R (R5%, R10%, R5-20), AX and Z5% values of IOS in patients with nephrotic phase were higher than remission patients and control group while spirometry indices of PEF% and MEF25-75% were lower.

--Z scores of MEF25-75 were significantly negatively correlated with z scores of R5, R10, Z5 and Fres while they were significantly positively correlated with z scores of X values (5,10,15 and 20 Hz).

--Z scores of FEV1/FVC significantly negatively correlated with z scores of R values (R5, R10), Z5 and AX and positively correlated with z scores of X values (X5, X10, X15 Hz).

Conclusively, this investigation indicated that respiratory functions, as evaluated by IOS and spirometry, were compromised throughout the nephrotic phase of the disease in NS patients, as well. Given its high connection with spirometry, IOS is a potentially beneficial tool to detect this disease in young children.

Source: https://onlinelibrary.wiley.com/doi/10.1002/ppul.25589?af=R
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