Study finds, Risk Factors for Endophthalmitis Following Open
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A Study was conducted to determine the rate of endophthalmitis and assess the risk factors for development of endophthalmitis following open globe injury (OGI).

A retrospective chart analysis of all OGI patients was carried out. Intravitreal injection or intraocular surgery within 30 days of injury or less than 30 days of follow-up were all ruled out. The report involved 586 open globe injuries out of a total of 993. The rate of endophthalmitis was the primary outcome measure.

Results:
--In this study, 25/586 eyes had endophthalmitis. Of these, 12/25 eyes presented with endophthalmitis and 13/25 eyes developed endophthalmitis after globe closure.

--Multivariate analysis identified time to globe repair (OR 4.5), zone I injury (OR 3.6), and need for additional surgery (OR 5.5) as factors associated with increased risk of developing endophthalmitis.

--Subconjunctival antibiotic injection at the time of globe closure (OR 0.3) was associated with decreased risk of developing endophthalmitis.

Finally, prompt globe closure and subconjunctival antibiotics can help to reduce the risk of endophthalmitis in patients with OGI. Furthermore, a single dose of systemic prophylactic antibiotics, as well as intravitreal antibiotics if IOFB removal is delayed, were found to have little effect on the incidence of endophthalmitis.

Source: https://www.dovepress.com/risk-factors-for-endophthalmitis-following-open-globe-injuries-a-17-ye-peer-reviewed-fulltext-article-OPTH
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