Study finds, Role of Atopy in the Choroidal Profile of Kerat
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While traditionally thought to be a non-inflammatory disease, evidence of an inflammatory basis for keratoconus (KC) is mounting. It was recently discovered that KC patients have a thicker choroidal layer (CT). Atopy has been linked to the development of KC among inflammatory disorders, so the aim of this study was to see whether the increased CT in KC patients was due to atopy.

This is an analytical cross-sectional study of patients with KC. Patients were classified as atopic and non-atopic according to their atopy history (allergic rhinoconjunctivitis (AR), asthma (AA) and/or atopic dermatitis (AD)) and were also classified based on their eye rubbing habits.

Choroidal profile of all subjects was evaluated using a Spectralis optical coherence tomography (OCT) device with enhanced depth imaging (EDI) mode. CT was measured and compared between groups at the center of the fovea and at 500 microm intervals along a horizontal section. A multivariable analysis, adjusted for sex, age, spherical equivalent, history of medication and atopy, was performed to assess the influence of atopy in CT.

--Of the 80 patients included, 51 were atopic and 29 non-atopic.

--Atopic patients showed a thicker choroid in every measured location than the non-atopic patients (mean subfoveal CT 391.53 microm vs 351.17 microm, respectively), although the differences were not statistically different.

--The multivariable analysis revealed that being atopic makes the choroid statistically thicker, on average, 55.14 microm, when compared to non-atopic patients.

--Furthermore, patients who are frequent eye rubbers have significantly thicker choroids than non-rubbers.

In particular, Atopic KC patients appear to have thicker choroids than non-atopic KC patients, implying that atopy can play a role in the choroidal profile of KC.