Study finds, SS-OCT changes and visual acuity among Palestin
Retinitis pigmentosa (RP) is a heterogeneous group of inherited ocular diseases that results in progressive retinal degeneration. This study aims to describe different Swept-source Optical Coherence Tomographic (SS-OCT) changes in Palestinian RP patients and to explore possible correlations with Visual Acuity (VA).

A cross-sectional observational study was conducted on Retinitis Pigmentosa patients diagnosed with RP. Full history and ocular examination were made. SS-OCT imaging was done for all eyes assessing the presence of cystoid macular edema, epiretinal membrane, macular holes, and external limiting membrane, ellipsoid zone status. Also, central macular thickness and choroidal vascular thickness were measured.

Results:
--The study was run on 161 eyes of 81 patients; 53 males and 28 females. The average age at examination was 26.1 years.

--26 were of syndromic RP patients, mostly Usher syndrome; 20 eyes. The mean Logaritmic minimal angle of resolution (LogMAR) of Best Corrected Visual Acuity (BCVA)of the study sample was 0.66±0.7.

--The most prevalent change was cystoid macular edema [28 eyes], followed by epiretinal membrane [17eye].

--A macular hole was noted only in one eye (0.6%). Ellipsoid zone and external limiting membrane were absent in 55 eyes and 60 eyes.

--Vitreous hyperreflective foci were found in 35 eyes. LogMAR of BCVA was associated significantly with cystoid macular edema, ellipsoid zone, and external limiting membrane.

In particular, a comprehensive SS-OCT examination revealed morphologies that differed from those seen in other groups. Early or middle stages of the illness may be indicated by cystoid macular edema and vitreous hyperreflective foci. The length/width (area) of the ellipsoid zone +/- external limiting membrane and choroidal vascular thickness, which should be measured serially using high-resolution OCT, can be used to track disease development.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-02047-6
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