Study finds Sex specific associations of human milk long-cha
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Polyunsaturated fatty acids (PUFAs) may influence immune development. The association of PUFAs in human milk was examined with food sensitization and atopic dermatitis among breastfed infants.

Human milk was tested by gasliquid chromatography in a subgroup of 1,109 motherinfant dyads from the CHILD Cohort study to quantify PUFAs such as arachidonic acid (ARA) and docosahexaenoic acid (DHA) (DHA). Skin prick monitoring for egg, peanut, cow's milk, and soybean sensitization was performed at 1 year of age, and pediatricians diagnosed atopic dermatitis. Breastfeeding exclusivity, family history of atopy, and other possible confounders were all accounted for in logistic regression analysis.

Results:
--Overall, 184 infants (17%) were sensitized to one or more food allergens and 160 (14%) had atopic dermatitis.

--Sex-specific associations were observed between these conditions and milk PUFAs. Girls receiving human milk with lower proportions of DHA had lower odds of food sensitization (aOR 0.35; 95%CI 0.12, 0.99 for lowest vs. highest quintile) and a clear dose-dependent association was observed for the ARA/DHA ratio (aOR 2.98; 95%CI 1.10, 8.06 for lowest vs. highest quintile).

--These associations were not seen in boys. Similar sex-specific tendencies were observed for atopic dermatitis.

Conclusively, human milk PUFA proportions and their ratios are associated with infant atopic conditions in a sex-specific manner. In female infants, a higher ratio of ARA/DHA may reduce the risk of food sensitization and atopic dermatitis.

Source: https://onlinelibrary.wiley.com/doi/10.1111/pai.13500?af=R
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