Study finds, Short-term outcomes in infants with mild Neonat
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Neonatal encephalopathy due to acute perinatal asphyxia is a major cause of perinatal brain damage. Moderate to severe neonatal encephalopathy is associated with high mortality and morbidity rates. The primary aim of this observational study was to assess the short-term outcomes in term neonates with mild neonatal encephalopathy due to perinatal asphyxia. A secondary aim was to identify predictors of poor prognosis by identifying the characteristics of these infants according to their short-term outcomes.

All infants with perinatal asphyxia were investigated retrospectively by the researchers. Seizures or irregular electroencephalography, abnormal brain MRI acquired during the first 4 weeks of life, and abnormal neurological test results at discharge were all considered abnormal short-term outcomes.

--In total, 110 term infants with perinatal asphyxia during the study period were screened and 61 were diagnosed with mild neonatal encephalopathy.

--11 of these infants had an abnormal short-term outcome. The median Thompson score at admission was significantly higher in infants with abnormal short-term outcomes than in those with normal short-term outcomes (5 [interquartile range, 4-5.5] vs. 2 [interquartile range, 1–3]).

--Receiver operating characteristic curve analysis showed that a cutoff value of 4 had high sensitivity and specificity (90.9 and 83.0 %, respectively) for prediction of an abnormal short-term outcome.

Finally, an abnormal short-term result, such as abnormal brain magnetic resonance imaging findings, was observed in 18% of infants with moderate encephalopathy. In infants with moderate neonatal encephalopathy, the Thompson score at admission can be a useful indicator of an irregular short-term outcome.