Study finds, Trabecular bone texture analysis of conventiona
Trabecular bone texture analysis (TBTA) has been identified as an imaging biomarker that provides information on trabecular bone changes due to knee osteoarthritis (KOA).

Researchers examined how TBTA, conducted on knee radiographs, is associated to (i) KOA incidence and progression, (ii) total knee arthroplasty, and (iii) KOA treatment responses. The primary aims of this study are twofold: to provide (i) a narrative review of the studies conducted on radiographic KOA using TBTA, and (ii) a viewpoint on future research priorities.

Results:
--The search resulted in 219 papers. After title and abstract scanning, 39 studies were found eligible and then classified in accordance to six criteria: cross-sectional evaluation of osteoarthritis and non-osteoarthritis knees, understanding of bone microarchitecture, prediction of KOA progression, KOA incidence, and total knee arthroplasty and association with treatment response.

--Numerous studies have reported the relevance of TBTA as a potential bioimaging marker in the prediction of KOA incidence and progression.

--Only a few studies have focused on the association of TBTA with both OA treatment responses and the prediction of knee joint replacement.

Clear evidence of biological plausibility for TBTA in KOA, in particular, had already been shown. The review demonstrates the constant link between TBT and key KOA outcomes such as KOA radiographic incidence and progression. TBTA could give markers for clinical trial enrichment, increasing the screening of KOA progressors.

Source: https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02594-9
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