Study finds, Vocal Development in Tuberous Sclerosis Complex
A Study was conducted to assess early vocalizations as precursors to speech in audio-video recordings of infants with Tuberous Sclerosis Complex (TSC).

Researchers randomly selected 40 infants with TSC. They analyzed 74 audio-video recordings within a flexible software-based coding environment. During the recordings, infants were engaged in developmental testing.

Sllables per minute (volubility), the number of consonant-vowel combinations, such as ‘ba’ (canonical babbling), the canonical babbling ratio (CBR) (canonical syllables/total syllables) were analyzed and the data with 2 groups of typically developing (TD) infants was compared.

--Compared to TD infants in laboratory and all-day LENA recordings, entry into the canonical babbling stage was delayed in the majority of infants with TSC, and the canonical babbling ratio was low (TD mean = .346, SE = .19; TSC mean = .117, SE = .023).

--Volubility level in infants with TSC was less than half that of TD infants (TD mean = 9.82, SE = 5.78; TSC mean = 3.99, SE = 2.16).

Infants with TSC had delayed entry into the canonical stage and other antecedents of speech development, which could indicate poor linguistic and developmental outcomes.