Study finds, Zinc Status and Growth in Infants and Young Chi
A Study was conducted to determine the prevalence of low serum Zn (sZn) and its relationship with growth in the first three years of life in children with CF.

Researchers utilized data from infants with CF who were enrolled in a longitudinal study of nutrition and lung health and had sZn measured as part of clinical care. Cross-sectional correlations between sZn levels and growth z-scores were assessed by Pearson's correlation coefficient. To identify factors associated with sZn status and its association to longitudinal growth patterns, multiple regression analysis with repeated measures were performed using generalized estimating equations.

--A total of 106 sZn measurements from 53 infants were identified.

--17 infants had intermittent Zn insufficiency, defined as at least one sZn less than 70 mcg/dL in their first 3 years of life.

--There were no significant cross-sectional associations between sZn and growth z-scores.

--However, analysis of longitudinal growth patterns revealed that weight- and length-for-age z-scores in children with intermittent Zn insufficiency were lower during early infancy and their weight-for-length z-scores at age 3 years were also lower compared to those who were always Zn sufficient.

Conclusively, low sZn occurs in one-third of children with CF in the first 3 years of life. Cross-sectional and longitudinal analysis revealed discrepant associations between sZn and growth.