Study finds antibiotics affect breast milk microbiota in mot
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A team of researchers has found that mothers of preterm babies have highly individual breast milk microbiomes and that even short courses of antibiotics have prolonged effects on the diversity and abundance of microbes in their milk.

The study led by researchers from the University of Toronto and The Hospital for Sick Children was published in the journal Cell Host and Microbe.

The study is the largest to date of breast milk microbiota in mothers of preterm infants, and it is the first to show that antibiotic class, timing and duration of exposure have particular effects on the most common microbes in breast milk -- many of which have the potential to influence growth and immunity to disease in new-borns. Most antibiotic stewardship programs in neonatal intensive care focus on limiting use in newborns themselves. The current study adds to growing evidence that these programs should include a focus on mothers as well, says O'Connor, principal investigator on the study who is also a scientist in the Joannah & Brian Lawson Centre for Child Nutrition.

The researchers looked at 490 breast milk samples from 86 mothers whose infants were born preterm, during the first eight weeks after delivery. They found that the mothers' body mass index and mode of delivery influenced the breast milk microbiota, consistent with some other studies.

But the effects of antibiotics were the most pronounced, and in some cases, they lasted for weeks. Many of the antibiotic-induced changes affected key microbes known to play a role in fostering disease, or in gut health and metabolic processes that promote babies' growth and development.

Source: https://health.economictimes.indiatimes.com/news/diagnostics/study-finds-antibiotics-affect-breast-milk-microbiota-in-mothers-of-preterm-infants/77928419
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