Study finds, how mechanically ventilated preterm infants res
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The objective of this study was to utilize available bedside monitoring of intubated preterm infants to report upon respiratory and oxygenation changes (Resistance, Compliance, FiO2, and SpO2) following the first dose of albuterol. It was hypothesized that ventilator measures of dynamic Resistance will decrease, dynamic Compliance will increase, FiO2 will decrease, and percent time in hypoxemia will decrease after albuterol is administered.

Respiratory measurements (Resistance, Compliance, FiO2) and pulse oximetry (SpO2) patterns were downloaded from infants with less than 30 weeks gestational age during the first 2 months of life. Mechanically ventilated infants who received albuterol were included (n?=?33). Measurements were compared before and after first albuterol. Secondary analysis assessed subsequent doses.

Results:
--Median gestation and birthweight were 25 3/7 weeks and 730?g, respectively. Mean Resistance decreased post-albuterol.

--68% of infants were responders based on decreased Resistance. Compliance and FiO2 did not significantly differ.

--Percent time in hypoxemia (SpO2?less than 85%) decreased post albuterol. In responders, Resistance changes diminished with subsequent administration.

In conclusion, two-thirds of preterm infants had lower ventilator resistance, which was consistent with research that used formal pulmonary function monitoring. Albuterol had a mixed impact on delivered FiO2, but hypoxemia may be useful in assessing albuterol response.

Source: https://www.nature.com/articles/s41372-021-01071-0
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