Study finds, impaired pulmonary function as long-term respir
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Congenital lung malformations (CLM) are rare disorders and surgical intervention is the definitive treatment. The aim of the study was to evaluate the long-term lung function of patients with CLM after surgery compared to healthy children.

The study comprised 16 children with CLM and 30 age-matched healthy controls. Spirometry and the nitrogen-based Lung Clearance Index (LCI) were used to compare the two groups, as well as demographic data.

Results:
Mean ± SD age of the patients was 12.0 ± 5.4 years.

--The mean forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and forced expiratory flow between 25% and 75% of force expiration (FEF25-75) predicted was, 86.68 ± 16.65, 88.00 ± 14.58, 97.44 ± 9.89, and 79.00 ± 26.41, respectively in the patient group.

--Patients with CLM had significantly lower values in FEV1, FVC, FEF25-75 than healthy controls.

--While the mean LCI2,5% value in patients' group was 8.33 ± 1.52, it was 7.28 ± 0.80 in healthy controls.

--Strong inverse correlation between LCI and FEV1, FEV1/FVC was detected in the patient group.

In conclusion, this study found that patients who had surgery for CLM have impaired pulmonary function when compared to healthy children, and LCI may be more reliable than spirometry in detecting airway illnesses early.

Source: https://onlinelibrary.wiley.com/doi/10.1111/ped.14488?af=R
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