Study finds, link between Optical microangiography and progr
A Study was conducted to evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG).

64 eyes of 40 POAG patients with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography (OCT) examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters, baseline hemifield mean deviation (MD), baseline quadrant OCT (retinal nerve fiber layer [RNFL] and ganglion cell inner plexiform layer [GCIPL] thickness) and OMAG (peripapillary and macular perfusion density [PD] and vessel density [VD]) on the rate of RNFL change was evaluated using linear mixed models.

--Average (±SD) MD, RNFL and GCIPL thickness of the analyzed quadrants at baseline were -5.5±2.9 dB, 96.5±17.9 µm, and 73.8±8.6 microm, respectively.

--Peripapillary PD and VD in the quadrant were 44.6±5.9% and 17.5±2.2 mm/mm2 respectively.

--Rate of quadrant RNFL change was -1.8±0.6 microm/year. Multivariate mixed models showed that lower peripapillary PD and lower VD were significantly associated with faster rate of RNFL loss.

In POAG, lower baseline peripapillary PD and VD assessed with OMAG were substantially linked with a faster rate of RNFL loss. These images provide information on glaucoma progression risk and the rate of disease development.