Study finds long-term impacts of Appendectomy
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
This research shows that in patients who have undergone an appendectomy, the risk of inflammatory bowel disease, sepsis, and colorectal cancer is increased.

The purpose of this study by the International Journal of Colorectal Disease was to evaluate the potential long-term impacts of appendectomy, with a focus on inflammatory bowel disease, infection, and colorectal cancer.

Adult patients who received appendectomy were identified. The control group consisted of patients who did not receive appendectomy were matched by baseline characteristics including comorbidities and frequency of healthcare resource utilization. The primary outcome was the incidence rate ratio (IRR) of Crohn’s disease, ulcerative colitis, Clostridium difficile infection, sepsis, and colorectal cancer after appendectomy or the index date.

Investigators identified 914,208 patients who underwent appendectomy, and after matching with control patients, a total of 486,844 patients were included for analysis.

--Patients who underwent appendectomy showed a significantly higher incidence of Crohn’s disease and ulcerative colitis compared to the control group during the 5-year follow-up period.

--The associations between appendectomy and Clostridium difficile infection, sepsis, and colorectal cancer were all found to be significant.

In conclusion, patients who underwent appendectomy may be at increased risk for developing Crohn’s disease, ulcerative colitis, Clostridium difficile infection, sepsis, and colorectal cancer.

Source: https://doi.org/10.1007/s00384-021-03886-x
1 share
Like
Comment
Share