Study finds, pharmacological dilation on intraocular pressur
A Study was conducted to assess changes in intraocular pressure (IOP) 1 hour after pharmacological dilation in eyes treated with laser peripheral iridotomy (LPI) and untreated fellow eyes of primary angle closure suspects (PACS).

A total of 889 PACS participants aged 50 to 70 years with LPI in one randomly selected eye and a fellow untreated eye were included. All participants underwent comprehensive examinations before and at 2 weeks, 6 m, 18 m, 36 m, 54 m, and 72 m after LPI. IOP was measured using Goldmann applanation tonometry before and 1 hour after pharmacological dilation.

--The mean pre-dilation IOP in the untreated eyes was 14.8±2.7 mmHg, which increased to 16.4±2.7 mmHg after pharmacological dilation.

--The treated and untreated eyes had similar pre-dilation and post-dilation IOP.

--The average post-dilation IOP elevation was 1.5 mmHg in the treated eyes and 1.6 mmHg in the untreated eye without significant differences.

--Lower pre-dilation IOP, smaller AOD500, smaller ARA500, smaller TISA500, and larger Iarea were associated with post-dilation IOP elevation 5 mmHg and greater.

--Three untreated and one treated eye developed acute angle closure (AAC) after dilation during the 72 m follow-up.

In the end, IOP levels are identical in the after dilution of treated and untreated eyes, and even in PACS there is a very minimal possibility that AAC will develop. It is not advisable to have the routine LPI before dilating PACS pupils.