Study finds test of protein levels in the eye a potential pr
In this study, researchers used samples of eye fluid from 80 patients who were previously scheduled for eye surgery. The fluid extracted during these surgeries is typically discarded. Researchers tested the eye fluid to determine the levels of amyloid-β and tau proteins, and correlated those levels to the results of a baseline cognitive test. Low levels of these biomarker proteins were significantly associated with lower cognitive scores among the patients.

"These findings could help us build an accessible, and minimally invasive test to determine Alzheimer's disease risk, especially among patients with eye disease," says Lauren Wright, MD, first author on the study and ophthalmology fellow at BMC. "We noted that some of the participants who had low levels of protein biomarkers in their eye fluid already had signs of mild to moderate dementia based on their cognitive scores."

These results reaffirm previous studies suggesting that patients with eye disease are at-risk for the development of AD, and suggest that further investigation in patients with eye disease may yield results that could be generalizable to larger populations.

"This is a great step in discovering the eye's potential role in diagnosing preclinical Alzheimer's disease, and further study is needed comparing protein biomarkers in the eye with more in-depth neurological testing," adds Manju Subramanian, MD, senior author, principal investigator, and ophthalmologist at BMC.

Read more: https://pxmd.co/w7JK1
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