Study finds, the Efficacy and Safety of Tranexamic acid in H
The present meta-analysis was conducted to evaluate the efficacy and safety of the application of tranexamic acid (TXA) in patients undergoing high tibial osteotomy (HTO).

A combined searching strategy of subject words and random words was adopted. After testing for potential publication bias and/or heterogeneity, researchers aggregated variables by using the random-effect model. The primary comparison outcome measures were total blood loss, hemoglobin decrease, drain output, wound complications, thrombotic events, and blood transfusion rate of the TXA group versus control.

--A total of 5 studies were included involving 532 patients. The results showed that there were significant differences in the two groups concerning total blood loss, hemoglobin decrease on postoperative day (POD) 1, 2, and 5, drain output and wound complications.

--Nonsignificant differences were found in the incidence of thromboembolic events (RR = 0.46) and blood transfusion rate (RR = 0.25).

Conclusively, this meta-analysis of the available evidence demonstrated that TXA could reduce total blood loss, hemoglobin decrease, drain output, and wound complications without increasing the incidence of thromboembolic events in patients undergoing HTO.