Study finds the impact of High CPAP & NIPPV in Preterm Neona
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A Study was conducted to evaluate the physiological impact of high continuous positive airway pressure (CPAP) (more than 9?cmH2O) vs. non-invasive positive pressure ventilation (NIPPV) at equivalent mean airway pressures.

Preterm newborns were used in alternating mode in this cross-over trial with high CPAP or NIPPV. After 30 minutes, left and right ventricular heart output and breath index work were evaluated, patients re-started and a similar procedure was followed.

Results:
--15 infants with mean (SD) postmenstrual age 32.7 (3.0) weeks, and weight 1569 (564) grams were included.

--No differences in LVO [320 vs. 331 mL/kg/min] or RVO [420 vs. 437 mL/kg/min] were noted during high CPAP vs. NIPPV, along with no differences in work of breathing indices.

Finally there were no deleterious effects on cardiac output or breathing activity compared to the corresponding mean airway pressure of high CPAP pressures compared to NIPPV.

Source: https://www.nature.com/articles/s41372-021-01122-6
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