Study finds various Clinical features of cases with Retinal
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A Study was conducted to report the clinical findings of the patients with retinal pigment epithelium (RPE) aperture secondary to age-related macular degeneration (AMD).

Review of the medical records of patients with RPE aperture accompanied by AMD was performed. Age, best-corrected visual acuity (BCVA), images of spectral domain optical coherence tomography, short-wave fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography, and retinal sensitivity measured with microperimetry were investigated . The change in visual acuity or the area of the aperture during the follow-up period was analyzed.

--5 eyes of 5 patients were included in the analysis. The mean age at presentation was 78.6±9.1 years. The average length of follow-up was 23.6±17.9 months.

--The RPE apertures appeared as round, either at the apex or at the base of PED, with no evidence of accompanying CNV but subretinal detachment (SRD) above the aperture.

--On FAF, the apertures appeared as sharply demarcated round areas of hypoautofluorescence.

--The FA revealed sharply demarcated round areas of window defects in the early and mid-phase with leakage in the late phase corresponding to SRD. The area of apertures enlarged during the follow-up period.

--Mean BCVA got worse from 0.20 logMAR at the initial presentation to 0.39 logMAR at the last visit. The retinal sensitivity was reduced but partly preserved above the area of aperture.

RPE aperture was discovered in some patients with drusenoid PED caused by AMD. During the follow-up, it grew larger. The capacity to see clearly had diminished. The sensitivity of the retina was reduced, but it was partially preserved.