Study finds, various Influenza-associated Neurologic Complic
A Study was conducted to define the incidence and characteristics of influenza-associated neurologic complications in a cohort of children hospitalized at a tertiary care pediatric hospital with laboratory-confirmed influenza, and to identify associated clinical, epidemiologic, and virologic factors.

Historical cohort study of children 0.5-18.0 years-old hospitalized with laboratory-confirmed influenza was done. Children with immune compromise or a positive test due to recent receipt of live virus vaccine or recently resolved illness were excluded. Influenza-associated neurologic complications were defined as new-onset neurologic signs/symptoms during acute influenza illness without another clear etiology.

--At least one influenza-associated neurologic complication was identified in 10.8% of hospitalizations with laboratory-confirmed influenza.

--Seizures (n=97) and encephalopathy (n=44) were the most commonly identified influenza-associated neurologic complication, although an additional 20 hospitalizations had other influenza-associated neurologic complications.

--Hospitalizations with influenza-associated neurologic complications were similar in age and influenza type (A/B) to those without.

--Children with a pre-existing neurologic diagnosis (n=326) had a higher proportion of influenza-associated neurologic complications compared with those without (22.7% vs 6.4%).

--Presence of a pre-existing neurologic diagnosis (aOR 4.6), lack of seasonal influenza vaccination (aOR 1.6), and age less than 5 years (aOR 1.6) were independently associated with influenza-associated neurologic complications.

Conclusively, Influenza-associated neurologic complications are common in children hospitalized with influenza, particularly those with pre-existing neurologic diagnosis. Vaccination is recommended and may help prevent influenza-associated neurologic complications in children.