Study observes, Accelerated osteoarthritis in Women with PCO
Osteoarthritis (OA) is the most common form of arthritis with multiple risk factors implicated including female sex and obesity. Polycystic ovary syndrome (PCOS) commonly affects women of reproductive age and these women are at higher risk of developing metabolic syndrome and thus likely to represent a high-risk group for early OA development.

A Study was conducted to assess the prevalence and incidence of knee, hip and hand osteoarthritis (OA) in women with polycystic ovary syndrome (PCOS) when compared with age-matched controls.

Results:
--The prevalence of hospital treated knee, hip and hand OA was 5.2% in women with PCOS diagnosis. It was 73% higher than that seen in age-matched controls.

--Significantly higher incidence rates were observed in the PCOS cohort compared with the age-matched controls during the follow-up period (up to 20 years), with the following hazard ratios (HR): 1.9 for knee, 1.8 for hand and 1.3 for hip OA.

--After excluding women with obesity, similar associations were observed for knee and hand OA. However, risk of developing hip OA was no longer significant.

In conclusion, as compared to age-matched controls, women with PCOS exhibited a greater prevalence and accelerated onset of OA of both weight and non-weight bearing joints.

Source: https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02604-w
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