Study of peripapillary retinal nerve fiber layer thickness i
The retina of diabetic patients undergoes neurodegenerative changes, in addition to vascular changes. The aim of this study is to evaluate the peripapillary retinal nerve fiber layer (RNFL) thickness in type 2 diabetes mellitus (DM) patients compared to healthy controls, using optical coherence tomography (OCT) and to correlate it with glycemic control. A total of 90 patients were enrolled in the study. The study group included 120 eyes of 60 type 2 diabetes mellitus patients. Sixty eyes of 30 healthy participants served as the control group. All patients underwent an OCT scan for peripapillary RNFL thickness measurement. Metabolic control of diabetes mellitus was assessed using glycosylated hemoglobin (HbA1c).

An independent sample t-test was used for normally distributed variables. Pearson's correlation analysis was used to assess the correlation between HbA1c and retinal nerve fiber layer thickness. Right eye RNFL thickness was thinner in diabetic patients than controls, with a statistically significant P value in the superior quadrant and inferior quadrant. The average, superior, and inferior RNFL thickness in the left eye was significantly thinner in diabetic patients as compared to controls. No significant correlation was found between HbA1c and retinal nerve fiber layer thickness. The peripapillary retinal nerve fiber layer is thinner in diabetic patients as compared to controls. This is the first study of its kind, among diabetic patients in Goa, which makes this study unique.

Source:https://www.jcor.in/article.asp?issn=2320-3897;year=2021;volume=9;issue=1;spage=9;epage=13;aulast=Menezes
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