Successful Treatment of White Sponge Nevus with Oral Doxycyc
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White sponge nevus (WSN) is a rare and benign disease that usually affects the oral mucosa and manifests as white spongy plaques. Because it is usually clinically asymptomatic, treatment of WSN is focused on improving the aesthetics and texture of the mucosa. Given the low prevalence of this condition, description of the available therapeutic options is limited to isolated clinical case reports and short cases series.

A 46-year-old male non-smoker with no relevant personal history was seen for oral lesions that had been present since childhood. Clinical examination revealed bilateral, whitish, soft plaques that were located on the buccal mucosa and the lateral aspects of the tongue and remained adhered after scraping.

The patient had no similar lesions in other locations and reported no relevant family history. Although the lesions were asymptomatic, they had a significant aesthetic impact on the patient. A biopsy of one of the lesions on the buccal mucosa revealed epithelial hyperplasia, edema, and discrete cytoplasmic clearance in squamous cells. Taken together with the clinical context, these findings were compatible with WSN.

Treatment for 2 months with topical triamcinolone acetonide (0.1%) and retinoic acid (0.1%) in oral adhesive excipient resulted in no clinical improvement, and it was decided to begin treatment with oral doxycycline (100?mg/d) for 6 weeks. The extension and texture of the lesions improved by the end of the treatment cycle, providing an acceptable aesthetic result, and the patient remained stable for the next 6 months.