'Supercool' method triples organ survival
Supercooling human livers to -4C triples the time they can be kept before transplant compared with putting them on ice, US researchers say. It slows the metabolic rate to prevent damage, Nature Biotechnology reports. It means organs can be kept viable for more than a day, which researchers say could revolutionise organ transplants.

'Quite phenomenal'

The solution was to prepare the liver for supercooling by using protective agents that prevented freezing. Experiments on discarded human livers showed they could be kept for 27 hours, rather than the typical nine hours when the organs are stored on ice.

One of the researchers, Dr Reinier de Vries, said: "This is a big breakthrough in organ preservation. "This is the first time that we actually show that it is feasible to preserve human organs at sub-zero temperatures."

'Simulated transplant'

The livers functioned as expected - based on tests such as oxygen use, bile production and lactate metabolism, when they were brought back up to temperature.

They also survived a "simulated transplant" when they were connected back up to an artificial blood supply. The researchers could not experiment on organs that would have been suitable for transplant.

But they believe organs that started off healthier could be preserved much longer. "[It's] in the order of days, not sure how many," researcher Dr Korkut Uygun told BBC News.

"We obviously can only do these experiments with grafts that are not good enough for transplant and it is great that despite being organs that are already injured, our experiments can be preserved for over a day."

Source: https://www.bbc.com/news/health-49632609
Dr. S●●●●h C●●●●●●●i and 7 others like this2 shares
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Dr. V●●●●●●j D●●●i
Dr. V●●●●●●j D●●●i Obstetrics and Gynaecology
Very logical.
Sep 28, 2019Like