Superior Orbital Fissure Syndrome and Ophthalmoplegia Caused
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The varicella-zoster virus lies dormant in the dorsal root ganglia after a symptomatic chickenpox infection, usually in childhood. If the virus reactivates in the trigeminal ganglia, it can cause varicella zoster ophthalmicus, which can have severe ocular complications.

This article reports a case of a 73-year-old woman in severe immunosuppression due to treatment with mycophenolate mofetil, glucocorticosteroids, and a tumor necrosis factor-alpha inhibitor. The reactivation caused superior orbital fissure syndrome, which has only rarely been described in relation to varicella-zoster virus reactivation. In the presented case, the syndrome was seen along with severe encephalitis.

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