Supplemental Intraoperative Oxygen did not increase postoper
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Surgical site infections and wound-related complications are common and serious. The primary defense against bacterial infection is oxidative killing by neutrophils, which requires molecular tissue oxygen. Increasing inspired oxygen is an easy and effective way to augment tissue oxygen. This recent study suggests that supplemental oxygen did not increase postoperative mortality.

Whether supplemental oxygen worsens long-term mortality remains unclear, with contradictory trial results. The authors, therefore, tested the hypothesis that supplemental oxygen (80% vs. 30%) increases the hazard for long-term mortality. The study was published by the journal Anesthesiology.

The authors conducted a post hoc analysis of a large multiple crossover cluster trial in which more than 5,000 colorectal surgeries on 4,088 adults were allocated to receive either 30% or 80% inspired oxygen during general anesthesia. The authors assessed the effect of 80% versus 30% target-inspired oxygen on long-term mortality and calculated Kaplan–Meier survival estimates.

The study shows;
--A total of 3,471 qualifying colorectal surgeries performed in 2,801 patients were analyzed, including 1,753 surgeries in 1,577 patients given 80% oxygen and 1,718 surgeries in 1,551 patients given 30% oxygen.

--The observed incidence of death after a median of 3 yr was 13% in the 80% oxygen group and 14% in the 30% oxygen group. The estimated hazard ratio for mortality was 0.94.

Conclusively, in this post hoc analysis of a large, controlled trial, supplemental oxygen did not increase postoperative mortality.

Source: https://doi.org/10.1097/ALN.0000000000003694
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