Sustained Inflation Versus Intermittent Positive Pressure Ve
A Study was conducted to characterize respiratory function monitor (RFM) measurements of sustained inflations and intermittent positive pressure ventilation (IPPV) delivered non-invasively to infants in the Sustained Aeration of Infant Lungs (SAIL) trial and to compare vital sign measurements between treatment arms.

Researchers analyzed RFM data from SAIL participants at 5 trial sites. Researchers assessed tidal volumes, rates of airway obstruction and mask leak among infants allocated to SI and IPPV, and researchers compared pulse rate and oxygen saturation (SpO2) measurements between treatment groups.

Results:
--Among 70 SAIL participants (36 SI, 34 IPPV) with RFM measurements, 40 were spontaneously breathing prior to the randomized intervention.

--The median expiratory tidal volume (Vte) of SIs administered was 5.3 mL/kg. Significant mask leak occurred in 15% and airway obstruction occurred during 17% of SIs.

--Among 34 control infants, the median Vte of IPPV inflations was 4.3 mL/kg (IQR 1.3-6.6). Mask leak was present in 3% and airway obstruction was present in 17% IPPV inflations.

--There were no significant differences in pulse rate or SpO2 measurements between groups at any point during resuscitation.

Finally, the SAIL trial's expiratory tidal volumes of SI and IPPV inflations were significantly varied in both treatment arms. During resuscitation, the vital signs of both groups were similar. In this study subgroup, SI as operationalized in the SAIL trial was not superior to IPPV for promoting lung aeration after birth.

Source: https://www.jpeds.com/article/S0022-3476(21)00823-4/fulltext?rss=yes
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