Switching Skin Antiseptics Could Reduce Surgical Site Infect
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Alcoholic formulations of chlorhexidine gluconate (CHG) seem to be safe and effective in preventing surgical site infections in clean surgery, according to a review published online Sept. 1 in the Annals of Surgery.

Rickie G. Wade, from the University of Leeds in the United Kingdom, and colleagues conducted a systematic literature review and network meta-analysis to evaluate the efficacy of CHG- and povidone-iodine (PVI)-based skin antiseptics for preventing surgical site infections in adults undergoing clean surgery.

Based on 17 studies comparing five antiseptics in 14,593 individuals, the researchers found that the overall rate of surgical site infection was 3 percent. The most effective antiseptic was alcoholic CHG 4 to 5 percent, which halved the risk for surgical site infection versus aqueous PVI (relative risk [RR], 0.49; 95 percent confidence interval [CI], 0.24 to 1.02) and alcoholic PVI (RR, 0.51; 95 percent CI, 0.21 to 1.27). Only patients exposed to PVI experienced adverse events related to the antiseptic applications.

Alcoholic formulations of 4%–5% CHG seem to be safe and twice as effective as PVI (alcoholic or aqueous solutions) in preventing infection after clean surgery in adults. Our findings concur with the literature on contaminated and clean-contaminated surgery and endorse guidelines worldwide that advocate the use of alcoholic CHG for preoperative skin antisepsis.

“Our findings concur with the literature on contaminated and clean-contaminated surgery, and endorse guidelines worldwide which advocate the use of alcoholic CHG for preoperative skin antisepsis,” the authors write.

Source:https://journals.lww.com/annalsofsurgery/Abstract/9000/The_Comparative_Efficacy_of_Chlorhexidine.94275.aspx
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