Synchronized intermittent mandatory Ventilation with Heliox,
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This study aimed to investigate the beneficial effects of synchronized intermittent mandatory ventilation (SIMV) with heliox in newborn infants with meconium aspiration syndrome (MAS).

71 newborn infants with MAS in the neonatal intensive care unit (NICU) were enrolled in the trial. Infants treated with SIMV were randomized and divided into the heliox group (n=35) and control group (n=36). The heliox group received heliox for 6h followed by air oxygen mixed gas, and the control group received air oxygen mixed gas.

The primary outcome measures were PaO2/FiO2 (P/F) and the extubation time. The secondary outcome measures were the incidence of mechanical ventilation complications, hospital length of stay in the NICU, blood gas analysis, and inflammation markers.

Results:
--The P/F in the heliox group was significantly better than that in the control group.

--The extubation time and hospital length of stay in the NICU in the heliox group were shorter than those in the control group.

--The inflammation markers at 6h and myocardial injury markers at 24h were decreased compared with those at 0h, and those in the heliox group were more significantly decreased than those in the control group.

Heliox tends to be more successful than an airoxygen mixture in reducing the duration of ventilation and increasing carbon dioxide eliminations in infants with MAS receiving SIMV assistance.

Source: https://onlinelibrary.wiley.com/doi/10.1002/ppul.25390?af=R
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