Syndrome of Inappropriate ADH Secretion (SIADH) during chemo
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Introduction

The syndrome of inappropriate ADH secretion (SIADH) is attributed to excessive ADH release. It is defined as less than maximally dilute urine in the presence of plasma hypoosmolality (hyponatremia), without volume depletion or overload, emotional stress, pain, diuretics or other drugs that stimulate ADH secretion. The exclusion of abnormalities in cardiac, hepatic, renal, adrenal and thyroid functions is also essential before SIADH can be diagnosed.

Since its initial description 1957 by Schwartz et al., SIADH has been related to a wide range of causes, such as pulmonary, central nervous system (CNS) and endocrine disorders, cytotoxic agents, malnutrition, fluid overload, various drugs and surgical interventions. Malignancies associated with clinically relevant SIADH are CNS, gastrointestinal tract, bladder, endometrial, adrenal cortex, breast cancer, thymoma, lymphoma, and most frequently small cell lung cancer [1]......

https://www.omicsgroup.org/journals/syndrome-of-inappropriate-adh-secretion-siadh-during-chemotherapy-with-carboplatinpaclitaxel-for-metastatic-fallopian-tube-cancer-2165-7548-1000262.php?aid=57371
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