Synovitis and Bone marrow lesions are associated with Sympto
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A Study was conducted to systematically review observational studies for the association between features detected on ultrasound (US) and magnetic resonance imaging (MRI) and, symptoms, signs and radiographic progression of hand osteoarthritis (OA).

Quality of studies was assessed using the Newcastle-Ottawa scales and data were extracted. Odds ratios (OR) and linear regression coefficients and 95% confidence intervals (CI) were pooled using the random-effects model (METAN package, Stata v16.1). Heterogeneity and publication bias were assessed.

Results:
--32 studies using US and MRI comprising 1,350 and 638 participants respectively were included.

--While only grey-scale synovitis (GSS) associated with AUSCAN-pain; 0-20 scale for , US-detected osteophytes, GSS and power Doppler (PD) as well as MRI-detected bone marrow lesions (BMLs), synovitis, osteophytes, and central bone erosions (CBEs) were associated with joint tenderness.

--US-detected GSS and PD associated with radiographic progression of CBEs [pooled ORs 5.37, 5.08], osteophytes [pooled ORs 5.17, 6.45], and joint space narrowing (pooled ORs 4.28, 4.36) whilst MRI-detected synovitis and BMLs associated with increasing KL grades with pooled ORs 2.92, 2.54 respectively.

Tenderness was linked to structural and inflammatory changes observed by ultrasound and MRI, while articular inflammation and subchondral bone damage were linked to radiographic hand OA progression. The relationship between these changes and pain was skewed.

Source: https://www.sciencedirect.com/science/article/abs/pii/S1063458421006993?dgcid=rss_sd_all
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