Systemic inflammation and the relationship between periodont
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This study shows that those individuals who were edentulous or had severe periodontitis had a significantly increased risk of all-cause mortality.

The aim was to investigate the role of systemic inflammation in the relationship between periodontitis, edentulism, and all-cause mortality in a group of men in Northern Ireland aged 58–72?years.

A representative sample of 1558 men had a detailed dental examination. The primary endpoint was death from any cause. Cox's proportional hazards model was used to assess the longitudinal relationship between periodontitis, edentulism, and all-cause mortality. Accelerated failure time modeling was performed to investigate the mediating role of systemic inflammation. The mean age of the men at baseline was 64.3 years.

- During a median follow-up of 17?years, 500 men died.

- After adjustment for confounding variables, compared to men with no/mild periodontitis, the hazard ratio for all-cause mortality amongst edentulous men was 1.52, and for those with severe periodontitis was 1.34.

- Systemic inflammation only accounted for a minor mediating pathway effect of 10%.

In particular, there was evidence in this group of men, that those who were edentulous or had severe periodontitis had a significantly increased risk of all-cause mortality. Systemic inflammation was not a major explanatory mediator of this association.

Journal of Clinical Periodontology
Source: https://doi.org/10.1111/jcpe.13510
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