T2 relaxation times of knee cartilage with knee pain and its
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Quantitative T2 cartilage MRI mapping has shown utility in research for the evaluation of early improvements in osteoarthritis. In a clinical population of knee disorders and patients and the features of disease and clinical symptoms, investigators tested the knee cartilage T2 relaxation times.

In this cross-sectional study, T2 mapping knee scans of 109 patients with knee pain who were referred for an MRI were collected. T2 relaxation times were calculated in 6 femoral and tibial regions of interest of full-thickness tibiofemoral cartilage. Its associations with age, sex, BMI, duration of complaints, disease onset (acute/chronic), and clinical symptoms were assessed with multivariate regression analysis. Subgroups were created of patients with abnormalities expected to cause predominantly medial or lateral tibiofemoral cartilage changes.

Results:
--T2 relaxation times increased statistically significantly with higher age and BMI.

--In patients with expected medial cartilage damage, the medial femoral T2 values were significantly higher than the lateral; in patients with expected lateral cartilage damage the lateral tibial T2 values were significantly higher.

--A traumatic onset of knee complaints was associated with an acute elevation. No significant association was found with clinical symptoms.

This study demonstrates age, BMI, and type of injury-dependent T2 relaxation times and emphasizes the importance of acknowledging these variations when performing T2 mapping in a clinical population.

Source: https://www.tandfonline.com/doi/full/10.1080/17453674.2021.1882131?af=R
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