TAVR Feasible, Comparable to Surgery in Rheumatic Heart Dise
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Patients with rheumatic aortic stenosis (AS) were excluded from transcatheter aortic valve replacement (TAVR) trials. The authors sought to examine outcomes with TAVR versus surgical aortic valve replacement (SAVR) in patients with rheumatic AS, and versus TAVR in nonrheumatic AS.

The authors identified Medicare beneficiaries who underwent TAVR or SAVR and then identified patients with rheumatic AS using prior validated International Classification of Diseases, Version 10 codes. Overlap propensity score weighting analysis was used to adjust for measured confounders. The primary study outcome was all-cause mortality. Multiple secondary outcomes were also examined.

Results:
-- The final study cohort included 1,159 patients with rheumatic AS who underwent aortic valve replacement (SAVR, n = 554; TAVR, n = 605), and 88,554 patients with nonrheumatic AS who underwent TAVR.

-- Patients in the SAVR group were younger and with lower prevalence of most comorbidities and frailty scores.

-- After median follow-up of 19 months, there was no difference in all-cause mortality with TAVR versus SAVR.

-- Compared with TAVR in nonrheumatic AS, TAVR for rheumatic AS was associated with similar mortality (15.2 vs. 17.7 deaths per 100 person-years after median follow-up of 17 months.

-- None of the rheumatic TAVR patients, less than 11 SAVR patients, and 242 nonrheumatic TAVR patients underwent repeat aortic valve replacement (124 redo-TAVR and 118 SAVR) at follow-up.

Conclusively, compared with SAVR, TAVR could represent a viable and possibly durable option for patients with rheumatic AS.

Source: https://www.jacc.org/doi/10.1016/j.jacc.2021.02.032
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