TSH alone is not an accurate biomarker for prediction of IUG
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Normal maternal thyroid function is essential for fetal growth and neurocognitive development. Intrauterine growth restriction (IUGR) is a complex condition arising from maternal, placental, or fetal mechanisms and any imbalance in thyroid function may lead to undesirable results for both mother and fetus. But this study states that TSH only is not an accurate biomarker for the prediction of IUGR.

The aim of this study by the Indian Journal of Obstetrics and Gynecology Research was to co-relate the level of thyroid-stimulating hormone (TSH) in clinically diagnosed cases of intrauterine growth restriction.

A prospective study was conducted wherein 120 clinically suspected cases of singleton IUGR pregnancies at 34-40 weeks of gestation were enrolled. Among these 120 clinically diagnosed cases of IUGR, only three antenatal mothers from rural backgrounds had TSH levels below 0.3 mIU/L. All three were vegetarians.

In these, hypothyroid antenatal mothers, the delivery outcomes were; one was born dead while the other two babies were born alive and required cesarean section. However, the two born alive had a very low birth weight; less than 1.5 kgs, and both needed admission to the neonatal intensive care unit.

The study concluded that role of TSH alone may not be accurate to be used as a biomarker for the prediction of IUGR.

Source: https://doi.org/10.18231/j.ijogr.2021.010
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Dr. J●i B●●●●i
Dr. J●i B●●●●i Obstetrics and Gynaecology
Good information.
Mar 25, 2021Like