TXA For the Prevention of Blood Loss after Vaginal Delivery
The use of tranexamic acid (TXA) reduces mortality due to postpartum hemorrhage. In the present study, published recently in NEJM, the authors investigated whether the prophylactic administration of tranexamic acid in addition to prophylactic oxytocin in women with vaginal delivery would decrease the incidence of postpartum hemorrhage.

4079 women in labor who had a planned vaginal delivery of a singleton live fetus at 35 or more weeks of gestation were randomized to receive 1 g of tranexamic acid or placebo, administered intravenously, in addition to prophylactic oxytocin after delivery. The primary outcome was postpartum hemorrhage, defined as blood loss of at least 500 ml, measured with a collector bag.

The results showed that women in the TXA group had a lower rate postpartum hemorrhage than those in the placebo group (7.8% vs. 10.4%) and also received additional uterotonic agents less often (7.2% vs. 9.7%). Other secondary outcomes did not differ significantly between the two groups. The incidence of thromboembolic events in the 3 months after delivery did not differ significantly between the tranexamic acid group and the placebo group .

Read more here: https://www.nejm.org/doi/full/10.1056/NEJMoa1800942
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Dr. H●●●●h D●●●i
Dr. H●●●●h D●●●i Obstetrics and Gynaecology
Good to know &!simple to prsctice
Aug 24, 2018Like