Technique behind world's 1st three-parent baby revealed
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Scientists have unveiled the details of a pioneering IVF technique that led to the birth of the world’s first ‘three-parent baby’ last year, providing new hope to families with inheritable mitochondrial disorders to have healthy children in the future. The procedure using mitochondrial replacement therapy (MRT) resulted in the birth of a healthy baby boy to a carrier of Leigh Syndrome, a progressive, fatal neurological disorder caused by a mutation in the mother’s mitochondrial DNA.

The researchers used an electrofusion technique to transfer the nuclear genome from the mother’s egg (leaving behind most of the mother’s mitochondria) to the cytoplasm of a donor egg containing only healthy mitochondria. This egg was then fertilised by the father’s sperm and transferred to the mother’s womb and a baby boy was born at 37 weeks after an uneventful pregnancy. Two methods of cell fusion have been used in the past by various groups researching MRT. Most groups have utilised a virus to accomplish cell fusion, however, the extent of viral DNA carryover is unknown.

http://www.hindustantimes.com/health-and-fitness/this-is-how-the-world-s-first-three-parent-baby-was-conceived-through-ivf/story-icj7It3Il3mxSDIl51INuI.html
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