Ten or more medications, often prescribed to older heart fai
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More than half of older patients hospitalized for heart failure, a progressive condition in which the heart doesn’t pump blood as well as it should, are discharged from the hospital with prescriptions for 10 or more medications, according to new research published today in Circulation: Heart Failure, an American Heart Association journal.

“High medication burden, also known as polypharmacy, is commonly associated with adverse events and reactions,” said senior study author. “As the treatment options for various conditions including heart failure expand and the population ages, it is becoming increasingly important to weigh the risks and possible benefits of multiple medications.”

To explore the medication burden of older adults with heart failure, researchers examined the medical charts of 558 adults, aged 65 and older, covered by Medicare and hospitalized for heart failure between 2003 and 2014 at one of 380 hospitals in the U.S. All were participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a large nationwide prospective observational cohort of over 30,000 participants that began in 2003 and continues with ongoing follow-up.

For this analysis, the number of medications for each patient was tallied at hospital admission and discharge. Medicines were categorized by the primary condition they treat: heart failure; other types of heart disease (such as aspirin and statin drugs for coronary heart disease); or non-heart-related (such as medications for lung, kidney disease or Type 2 diabetes).

Researchers found:

-- Upon admission to the hospital, 84% of the study participants took five or more medications, and 42% took 10 or more.
-- Participants were discharged from the hospital with prescriptions for more medications than when they were admitted: 95% were prescribed five or more medications; and 55% were prescribed 10 or more at hospital discharge.
-- Polypharmacy has become increasingly common, with 10 or more medications prescribed at discharge for 41% of participants hospitalized between 2003-2006, and 68% for those hospitalized between 2011 and 2014.
--Most of the medications taken by participants with heart failure were not to treat heart failure or a heart condition.

“The medication burden for older adults with heart failure was higher following a heart failure hospitalization. Some of these drugs may be appropriate. However, a prior work has shown that many patients are discharged with prescriptions for medications that can worsen heart failure. This supports the ongoing need for improved and routine medication review processes prior to hospital discharge, and particularly in the immediate post-discharge period where the risk of hospital readmission is particularly high,” said researchers.

Source: https://newsroom.heart.org/news/ten-or-more-medications-often-prescribed-to-older-heart-failure-patients-raises-concerns
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