Test to identify Drug-resistant TB bacteria quickly
The test is based on whole genome sequencing of Mycobacterium tuberculosis, the bacterium which causes tuberculosis.

A DNA test which will give a detailed analysis of every single mutation present in all tuberculosis bacteria has been developed, which will enable quick and accurate treatment with the most effective drug. This test, developed by MedGenome Labs — a clinical data-driven genetic diagnostics and drug discovery research organisation — can provide a detailed analysis of every single mutation present in any TB bacteria causing drug resistance, directly from the sputum.

The existing sputum smear microscopy, Cartridge Based Nucleic Acid Amplification Test (CB-NAAT) and culture tests are not only time-consuming but do not provide a detailed analysis of resistance developed by the patient to every single mutation in the bacteria

The test, called Spit Seq, has been validated on 100 samples in India, with 100 per cent sensitivity, and 98.04 per cent sensitivity in specific cases of multi-drug resistant tuberculosis. This is the first DNA test which has shown promise in identifying TB bacteria quickly.

The test helps to assess the mutations in the bacterium’s genome and allows clinicians to determine which drugs will work for the patient.

“The test now costs around ₹7,500 and takes around eight days. If the volumes increase, the cost can further reduce. We will soon publish our research in a journal. We are also working with the government to integrate the test in the public health programme. We are hoping the test should be available in the clinical market within three months,” Dr Ramprasad said.

Dr Subakar Kandi, a senior pulmonologist and professor at Osmania Medical College, said, “The process of analysing drug resistance is very long. Testing resistance is found for only four drugs. Hence, the patient has to wait until testing on all possible drugs is concluded. Repeated testing is found to lead to multiple changes in the course of the treatment. It is important that the tuberculosis medicine regime course is completed.”

Due to delayed diagnosis, dealing with multi-drug resistant tuberculosis is a Herculean task. There are an estimated 2.8 million cases of tuberculosis in India. There are 1.50 lakh multi-drug resistant tuberculosis patients in India.

Source: https://www.thehindu.com/news/national/karnataka/now-spit-seq-test-for-early-diagnosis-of-drug-resistant-tb/article28918702.ece
Dr. N●●●●g T●●●●●i and 52 others like this45 shares
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Dr. P●●●●●●a N K●●●●●n
Dr. P●●●●●●a N K●●●●●n Ophthalmology
A wonderful test
Aug 10, 2019Like1
Dr. K●●●●●e S●●●●●m
Dr. K●●●●●e S●●●●●m General Surgery
So nice to hear this advanced technology
Aug 11, 2019Like1
Dr. J●●●●●●a T●●●●●●e
Dr. J●●●●●●a T●●●●●●e Obstetrics and Gynaecology
Nice test
Aug 12, 2019Like