The Diverse Uses of 5-Fluorouracil in Dermatology
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5-fluorouracil (5-FU) is widely used for treatment of malignant and premalignant skin cancers; however, its use in other common cutaneous conditions has been less widely reported. Researchers investigated the off-label uses of 5-FU beyond malignant and premalignant skin disease.

A literature review searching multiple databases was conducted to evaluate the evidence for the off-label uses of 5-FU. The level of evidence was evaluated and selected accordingly listing the studies with the highest level of evidence first using the Oxford Centre of Evidence-Based Medicine 2011 guidance.

Results:
--The use of 5-FU was done for a wide range of noncancerous cutaneous indications including:
-Scarring (keloid, hypertrophic),
-Pigmentary disorders (vitiligo, idiopathic guttate hypomelanosis),
-Cutaneous infections (viral warts, molluscum contagiosum), inflammatory dermatoses (Darier's disease, Hailey-Hailey disease and sarcoidosis), and
-Cosmetic indications (photoaging, treatment of filler nodules and granulomas).

Conclusively, in selected patients, 5-FU can be as effective as more established treatments, with fewer side-effects.

Source: https://journals.lww.com/dermatologicsurgery/Abstract/2021/03000/5_Fluorouracil_in_Dermatology__The_Diverse_Uses.6.aspx
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