The First Clinical Trial to Support Vitamin D Therapy For Co
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A study in Spain has shown that high doses of calcifediol, an activated form of vitamin D, significantly reduced the need for ICU treatment of hospitalised Covid-19 patients.

Key Insights:

• Researchers randomly allocated 76 confirmed cases of Covid-19 into either oral calcifediol (50 patients) or no-calcifediol control (26 patients) groups on the day of the hospital admission.

• Oral calcifediol was given at high doses at 0.532 mg on the first day and then at 0.266 mg on the third and seventh day, and then weekly until discharge or admission to the intensive care unit (ICU).

• Calcifediol, also called 25-hydroxyvitamin D3, is the main metabolite (effector) of vitamin D3.

• All patients also received the best available standard care at that time, which was hydroxychloroquine plus azithromycin.

• Results revealed that 13 out of 26 patients (50%) in the control group were admitted to ICU, and two died in the end.

• In the calcifediol group, only one out of 50 (2%) required ICU admission, and none died.

• These results were statistically significant, equating to a 93% reduction in odds of ICU admission after adjusting for possible confounders (e.g., hypertension).

“Calcifediol seems to be able to reduce the severity of the disease, but larger trials with groups properly matched will be required to show a definitive answer,' said author.

Note: This study was conducted a few months ago when hydroxychloroquine has not yet been proven as ineffective for Covid-19, the study authors admitted.

Source: https://www.sciencedirect.com/science/article/pii/S0960076020302764
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