The Indian Council of Medical Research (ICMR) launched India
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This is important news for 2 reasons, which are:

1. India reports 27% of the global TB burden
2. The Bacille Calmette-Guerin (BCG) vaccine is over 100 years old and is partially effective in protecting young children, particularly from the most severe forms of TB

This is the first time a large preventive TB vaccine trial involving more than 12,000 healthy household contacts of newly diagnosed TB patients from across six states of India are set to be enrolled. These vaccines aim to prevent infection (pre-exposure) or prevent primary progression or reactivation of latent TB infection (post-exposure), all of which have a critical role to play in India’s big fight against TB!

For these trials, the six states including Delhi, Maharashtra, Odisha, Telangana and Karnataka, with two thousand participants from each state are to be enrolled over the next seven to eight months.

The vaccines being tested in this study are Immuvac and VPM1002. Both vaccines are being manufactured by Indian pharmaceutical companies.

VPM1002 is a genetically modified BCG vaccine derived from the Mycobacterium Bovis BCG subtype Prague characterized as rBCGÄureC::Hly+ and is administered intradermally.

The trials are likely to undergo three testing phases. In the first phase, a small group of individuals take the trial vaccine, in the second phase, it is given to those with characteristics that seem similar to those for whom this new vaccine is intended. In the last phase, it is administered to several thousands of individuals, thus tested for safety as well as efficacy.

Based on the results, recommendations are to be sent to the Union Ministry of Health and Family Welfare. Though the vaccines are manufactured by Indian pharmaceutical companies, the price of the vaccines will be set by the government.

M●●●●a K●●●a R and 3 others like this4 shares