The Studded Rectum: Clinical Sign Points to Colorectal Cance
The colorectal cancer predisposition syndrome called MYH-associated polyposis (MAP) is a diagnostic challenge. Resulting from mutations in a gene that’s critical to base excision DNA repair, MAP overlaps clinically with mild familial adenomatous polyposis (FAP) and other hereditary colon cancer syndromes. Because MAP is recessively inherited, the affected individual may have no family history to tip off the clinician to its presence....
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