The effect of acemannan in implant placement with simultaneo
Acemannan, a linear polysaccharide produced by Aloe vera, has been shown to have important biological effects promoting wound healing and tissue regeneration.

The aim of this randomized clinical trial was to investigate the impact of acemannan in guided bone regeneration (GBR) with simultaneous implant placement.

Twenty patients were randomly allocated to a test group and a control group. Twenty implants were placed with simultaneous GBR. Radiographic measurements were conducted on cone-beam computed tomography (CBCT) scans immediately post-surgery and at 3 and 6 months. Vertical and horizontal dimensions of the buccal bone were measured at the implant platform (0) and at points 2, 4, 6, and 8?mm apically.

The dimensional reduction of vertical and horizontal buccal bone was significantly smaller in the test group at 3 months postoperative at every position measured (0, 2, 4, 6, 8 mm), but the difference was not statistically significant at 6 months.

Overall, acemannan was found to be a safe and predictable biomaterial for GBR, which resulted in enhanced dimensional stability of the regenerated tissue at 3 months.

International Journal of Oral & Maxillofacial Surgery