The effect of dexmedetomidine on intraoperative blood glucos
Dexmedetomidine showed no effect on intraoperative hyperglycemia in elderly patients undergoing non-cardiac major surgery.

This was a secondary analysis of a randomized controlled trial. Patients in the dexmedetomidine group received a loading dose of dexmedetomidine followed by a continuous infusion for 1 h before the end of surgery. Patients in the control group received volume-matched normal saline at the same time interval. The primary outcome was the incidence of intraoperative hyperglycemia (blood glucose higher than 10 mmol/L).

303 patients in the dexmedetomidine group and 306 patients in the control group were analyzed.

- The incidence of intraoperative hyperglycemia showed no statistical significance between the dexmedetomidine group and the control group.

- Median value of glycemic variation in the dexmedetomidine group was slightly lower than that in the control group.

- In multivariable logistic analysis, history of diabetes, higher baseline blood glucose, and prolonged surgery time were independent risk factors of hyperglycemia.

Conclusively, dexmedetomidine presented no effect on intraoperative hyperglycemia in elderly patients undergoing major non-cardiac surgery.

BMC Anesthesiology
Source: https://doi.org/10.1186/s12871-021-01360-3
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