The effect of vitamin D on the occurrence and development of
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Vitamin D supplements are beneficial in patients with colorectal carcinoma and also reduces the incidence of its development according to this meta-analysis.

There has been a lot of controversies about the correlation between vitamin D and colorectal cancer (CRC). In this meta-analysis, investigators purposed to explore the relationship between vitamin D and the incidence of CRC/the prognosis of CRC.

A systematic search for articles in databases (Pubmed, Web of Science, EBSCO, and Cochrane Library) was carried out. The primary outcomes were the incidence rate of CRC and the long-term survival of patients with CRC.

The findings were;
--According to the estimated pooled OR from 21 eligible studies, covering 904152 people, the use of vitamin D was inversely associated with the incidence of CRC.

--Among the four studies included in this meta-analysis, covering 7486 patients, compared the overall survival (OS) of CRC between the vitamin D users and the non-users. Based on the estimated pooled HR, vitamin D potentially improved the long-term survival of CRC patients.

Conclusively; this meta-analysis demonstrates that vitamin D not only has a positive impact on the incidence of CRC from either the dietary or supplemental sources but also benefits clinical outcomes and improves the long-term survival of CRC patients.

International Journal of Colorectal Disease
Source: https://doi.org/10.1007/s00384-021-03879-w
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